1-Propionyl-lysergic acid diethylamide (commonly known as 1P-LSD or 1P-LAD) is a novel semi-synthetic psychedelic substance of the lysergamide chemical class that produces “classical psychedelic” effects reported to be near-identical with those of LSD when administered. Like ALD-52, it is principally theorized to act as a prodrug for LSD, not exerting any activity until it has been converted into LSD after entering the body, although there is ongoing speculation that it might possess some intrinsic activity in its own right.
The structural resemblance 1P-LSD shares with LSD suggests an extremely similar effect profile, with perhaps the only significant differences stemming from variations in the rate of absorption, duration, metabolism, and excretion of the compound (i.e. its pharmacokinetic factors). Due to the lack of research relating to this substance, all following discussion relating to its pharmacology is purely based on its structural and subjective effect similarities to LSD and other designer lysergamides.
1P-LSD first appeared as a research chemical sold by grey market vendors in January 2015.
Although it was likely discovered in an academic setting, it is unknown who first synthesized 1P-LSD, as the substance does not appear in any academic literature pre-dating its arrival on the research chemical market.
Interestingly, the future usage of 1-akylated lysergamide derivatives as a means to bypass controlled substance laws banning LSD as a precursor was foreseen in a DEA report from 1988:
…a reduction in hallucinogenic activity may become acceptable to the U. S. clandestine chemist when he notes that lysergic acid amide is listed as a Schedule III substance in the CFR; therefore, structurally similar substances of this compound are exempted from the CsA amendment. A lucid argument can then be made that lysergic acid N,N-dimethylamide is derived from lysergic acid amide rather than LSD. Carrying this theme to the next logical step one would then assume that the 1-alkyl and 1-acyl derivatives of the N,N-dimethyl isomer would also not be controlled by the CsA amendment.
— Donald A. Cooper, Future Synthetic Drugs of Abuse, 1988